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Article

Detection of LINE-1 hypomethylation in cfDNA of Esophageal Adenocarcinoma Patients

24 Feb 2020

Abstract excerpt

DNA methylation plays an important role in cancer development. Cancer cells exhibit two types of DNA methylation alteration: site-specific hypermethylation at promoter of oncosuppressor genes and global DNA hypomethylation. This study evaluated the methylation patterns of long interspersed nuclear element (LINE-1) sequences which, due to their relative abundance in the genome, are considered a good surrogate...

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Share to Epigenetics and DNA Methylation
Share to Esophageal Cancer Research and Treatment

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PMID: 32102481
DOI: 10.3390/ijms21041547

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