Article
LINE-1 hypomethylation and mutational status in cutaneous melanomas.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research - 1 Apr 2016
Pramio Dimitrius T, Pennacchi Paula C, Maria-Engler Silvya S, Campos Antônio H J F M, Duprat João P, Carraro Dirce M, Krepischi Ana C V
Abstract excerpt
Epigenetic dysregulation is an important emerging hallmark of cutaneous melanoma development. The global loss of DNA methylation in gene-poor regions and transposable DNA elements of cancer cells contributes to increased genomic instability. Long interspersed element-1 (LINE-1) sequences are the most abundant repetitive sequence of the genome and can be evaluated as a surrogate marker of the global level of DNA...
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