A murine model of the human CREBRFR457Q obesity-risk variant does not influence energy or glucose homeostasis in response to nutritional stress.

doi:10.1371/journal.pone.0251895

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

A murine model of the human CREBRFR457Q obesity-risk variant does not influence energy or glucose homeostasis in response to nutritional stress.

PloS one - 1 Jan 2021

Kanshana Jitendra S, Mattila Polly E, Ewing Michael C, Wood Ashlee N, Schoiswohl Gabriele, Meyer Anna C, Kowalski Aneta, Rosenthal Samantha L, Gingras Sebastien, Kaufman Brett A, Lu Ray, Weeks Daniel E, McGarvey Stephen T, Minster Ryan L, Hawley Nicola L, Kershaw Erin E

Abstract excerpt

Obesity and diabetes have strong heritable components, yet the genetic contributions to these diseases remain largely unexplained. In humans, a missense variant in Creb3 regulatory factor (CREBRF) [rs373863828 (p.Arg457Gln); CREBRFR457Q] is strongly associated with increased odds of obesity but decreased odds of diabetes. Although virtually nothing is known about CREBRF's mechanism of action, emerging evidence...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Mass Index

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diet

Share to Disease Models, Animal

Share to Energy Metabolism

Share to Gene Knock-In Techniques

Share to Glucose

Share to Mutation, Missense

Share to Obesity

Source

Open in PubMed Open full text

Identifiers

PMID: 34520472
DOI: 10.1371/journal.pone.0251895
PMCID: PMC8439463

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A murine model of the human CREBRFR457Q obesity-risk variant does not influence energy or glucose homeostasis in response to nutritional stress.PMID 34520472Read ↗

A murine model of the human CREBRF <sup>R457Q</sup> obesity-risk variant does not influence energy or glucose homeostasis in response to nutritional stressSemantic proximity Read ↗

Limited Metabolic Effect of the CREBRFR457Q Obesity Variant in Mice.Semantic proximity Read ↗

The Role of Mammalian Creb3-Like Transcription Factors in Response to NutrientsSemantic proximity Read ↗

CREBRF variant increases obesity risk and protects against diabetes in Samoans.Semantic proximity Read ↗

CREBRF p.Arg457Gln Promotes Obesity and Improves Insulin Sensitivity by Promoting Preadipocyte Differentiation and Reducing Oxidative Metabolism in Gene-modified Pig ModelsSemantic proximity Read ↗

Changes in environmental stress over COVID-19 pandemic likely contributed to failure to replicate adiposity phenotype associated with Krtcap3.Semantic proximity Read ↗

The role of CREB-H transcription factor in triglyceride metabolism.Semantic proximity Read ↗

Loss of CTRP10 results in female obesity with preserved metabolic healthSemantic proximity Read ↗

A thrifty variant in CREBRF strongly influences body mass index in Samoans.Semantic proximity Read ↗

Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous miceSemantic proximity Read ↗

Integrative genomic analysis of CREB defines a critical role for transcription factor networks in mediating the fed/fasted switch in liverSemantic proximity Read ↗

Changes in behavior and gene expression induced by caloric restriction in C57BL/6 miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.