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Article

Genes related to SNPs identified by Genome-wide association studies of age-related hearing loss show restriction to specific cell types in the adult mouse cochlea.

Hearing research - 1 Oct 2021

Xue Na, Song Lei, Song Qiang, Santos-Sacchi Joseph, Wu Hao, Navaratnam Dhasakumar

Abstract excerpt

ARHL has been thought to result from disordered hair cell function and their loss. ARHL has a significant genetic component. We sought to determine the expression in the cochlea of genes associated with single nucleotide polymorphisms linked to ARHL. We find widespread and varying expression of genes associated with these SNPs in subtypes of cells in the cochlea identified by single-cell RNA sequencing. Genes...

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Identifiers

PMID: 34536825
DOI: 10.1016/j.heares.2021.108347

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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