Article

ER-to-Golgi transport machinery promotes the excessive cargo-triggered unfolded protein response

2025-12-17

Abstract excerpt

Disruptions to ER homeostasis trigger the unfolded protein response (UPR) to restore proteostatic balance. While defects in the secretory machinery are known to induce ER stress, it remains unclear whether specific trafficking components directly modulate UPR signaling. Here, we demonstrate that neuronal overexpression of the gap junction protein UNC-9 activates the IRE1-XBP1 arm of the UPR in C. elegans . Geneti...

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Literature Corpus work: bebc32aa-f7be-593c-a913-bbebc3f083c4
DOI: 10.64898/2025.12.15.694336

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