Article
Differential Associations of Apolipoprotein E ε4 Genotype With Attentional Abilities Across the Life Span of Individuals With Down Syndrome.
JAMA network open - 1 Sept 2020
D'Souza Hana, Mason Luke, Mok Kin Y, Startin Carla M, Hamburg Sarah, Hithersay Rosalyn, Baksh R Asaad, Hardy John, Strydom Andre, Thomas Michael S C
Abstract excerpt
Importance: Risk of Alzheimer disease (AD) is particularly high for individuals with Down syndrome (DS). The ε4 allele of the apolipoprotein E gene (APOE ε4) is associated with an additional risk for AD. In typical development, there is evidence that the APOE ε4 genotype is associated with an early cognitive advantage. Here we investigate associations of APOE ε4 with attention across the life span of individuals...
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