Article

Associations Among miR-33, APOE ε4, and Metabolic Markers in Down Syndrome Youth

2026-02-25

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Down syndrome (DS), caused by trisomy 21, is associated with intellectual disability and early metabolic and neurodegenerative alterations. Cholesterol homeostasis, regulated by microRNAs (miRNAs), miR-33 through ABCA1 and HDL cholesterol (HDL-c) biogenesis, influences cognitive decline linked to the <italic>APOE ε</italic> 4 isoform. <bold>Methods</bold>...

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Literature Corpus work: 90e0b2ef-9c79-5031-b710-709d016a3e18
DOI: 10.21203/rs.3.rs-8845542/v1

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