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Article

Intrahepatic cholangiocarcinomas with IDH1/2 mutation-associated hypermethylation at selective genes and their clinicopathological features.

Scientific reports - 25 Sept 2020

Lee Kyoungbun, Song Young Seok, Shin Yoonju, Wen Xianyu, Kim Younghoon, Cho Nam-Yun, Bae Jeong Mo, Kang Gyeong Hoon

Abstract excerpt

Intrahepatic cholangiocarcinoma (ICC) is a rare but fatal tumor. The isocitrate dehydrogenase 1 and 2 (IDH1/2) genes are known to be mutated in ICC. IDH1/2 mutations tend to be accompanied by enhanced hypermethylation at a subset of genomic loci. We sought to clarify the clinicopathological features, including prognostic value, of ICCs with IDH1/2 mutation-associated hypermethylation at a subset of genes. The...

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Identifiers

PMID: 32978444
DOI: 10.1038/s41598-020-72810-0
PMCID: PMC7519101

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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