Article
Generation of the SCN1A epilepsy mutation in hiPS cells using the TALEN technique.
Scientific reports - 23 Jun 2014
Chen Wanjuan, Liu Jingxin, Zhang Longmei, Xu Huijuan, Guo Xiaogang, Deng Sihao, Liu Lipeng, Yu Daiguan, Chen Yonglong, Li Zhiyuan
Abstract excerpt
Human induced pluripotent stem cells (iPSC) can be used to understand the pathological mechanisms of human disease. These cells are a promising source for cell-replacement therapy. However, such studies require genetically defined conditions. Such genetic manipulations can be performed using the novel Transcription Activator-Like Effector Nucleases (TALENs), which generate site-specific double-strand DNA breaks...
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