Article
Hypoxia Induces Mitochondrial Defect That Promotes T Cell Exhaustion in Tumor Microenvironment Through MYC-Regulated Pathways.
Frontiers in immunology - 1 Jan 2020
Liu Yi-Na, Yang Jie-Feng, Huang Dai-Jia, Ni Huan-He, Zhang Chuan-Xia, Zhang Lin, He Jia, Gu Jia-Mei, Chen Hong-Xia, Mai Hai-Qiang, Chen Qiu-Yan, Zhang Xiao-Shi, Gao Song, Li Jiang
Abstract excerpt
T cell exhaustion is an obstacle to immunotherapy for solid tumors. An understanding of the mechanism by which T cells develop this phenotype in solid tumors is needed. Here, hypoxia, a feature of the tumor microenvironment, causes T cell exhaustion (TExh) by inducing a mitochondrial defect. Upon exposure to hypoxia, activated T cells with a TExh phenotype are characterized by mitochondrial fragmentation,...
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