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Mitochondrial Genome Regulator TFAM Modulates Head and Neck Tumorigenesis Through Activation of Intracellular Metabolic Reprogramming and Oncogenic Effectors

2020-09-23

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<title>Abstract</title> <p><bold>Background:</bold> Mitochondrial defect is often observed in cancers while, in comparison with other metabolic cues, mitochondria mediated regulations in controlling tumorigenesis are less emphasized. Mitochondrial transcriptional factor A (TFAM) acts as a key regulatory factor to control mitochondrial DNA (mtDNA) replication and packing; the role of TFAM in modulating carcinogene...

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Literature Corpus work
46951941-99ea-5c28-944c-c65def61176c
DOI
10.21203/rs.3.rs-78709/v1
Open publication

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Mitochondrial Genome Regulator TFAM Modulates Head and Neck Tumorigenesis Through Activation of Intracellular Metabolic Reprogramming and Oncogenic EffectorsDOI 10.21203/rs.3.rs-78709/v1
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