Article
Vulvar cancer subclassification by HPV and p53 status results in three clinically distinct subtypes.
Gynecologic oncology - 1 Dec 2020
Kortekaas Kim E, Bastiaannet Esther, van Doorn Helena C, de Vos van Steenwijk Peggy J, Ewing-Graham Patricia C, Creutzberg Carien L, Akdeniz Kadir, Nooij Linda S, van der Burg Sjoerd H, Bosse Tjalling, van Poelgeest Mariette I E
Abstract excerpt
OBJECTIVE: There is great need for better risk stratification in vulvar squamous cell carcinoma (VSCC). Our aim was to define the prognostic significance of stratifying VSCC based on p16 and p53 immunohistochemistry (IHC) as surrogate markers for HPV and TP53 mutations. METHODS: A large retrospective cohort of surgically treated women with primary VSCC was used. VSCC were classified into three subtypes:...
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