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Article

Prognosis of HPV-independent, p53-wild-type vulvar squamous cell carcinoma: A systematic review and meta-analysis.

Gynecologic oncology - 1 Oct 2025

Fulgione Caterina, Inzani Frediano, Raffone Antonio, Raimondo Diego, Arciuolo Damiano, Ronchi Susanna, Marchiori Deborah, Maragliano Roberta, Neola Daniele, Vastarella Maria Giovanna, Cobellis Luigi, LA Rosa Stefano, Zannoni Gian Franco, Travaglino Antonio

Abstract excerpt

BACKGROUND: Vulvar squamous cell carcinoma (VSCC) is subdivided into TP53-mutant (TP53mut) and HPV-associated (HPV+). In recent years, a third group unrelated to TP53 mutation or HPV-association (TP53wt/HPV-) has emerged. However, its prognosis is unclear. OBJECTIVE: The aim of this study was to define the prognosis of TP53wt/HPV-VSCC through a systematic review and meta-analysis. METHODS: Electronic databases...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 40911975
DOI: 10.1016/j.ygyno.2025.08.028

Genes

TP53

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