Article
Strain-Dependent Modifier Genes Determine Survival in Zfp423 Mice.
G3 (Bethesda, Md.) - 5 Nov 2020
Alcaraz Wendy A, Liu Zheng, Valdes Phoebe, Chen Edward, Valdovino Gonzalez Alan G, Wade Shelby, Wong Cinny, Kim Eunnie, Chen Hsiang-Hua M, Ponn Alison, Concepcion Dorothy, Hamilton Bruce A
Abstract excerpt
Zfp423 encodes a transcriptional regulatory protein that interacts with canonical signaling and lineage pathways. Mutations in mouse Zfp423 or its human ortholog ZNF423 are associated with a range of developmental abnormalities reminiscent of ciliopathies, including cerebellar vermis hypoplasia and other midline brain defects. Null mice have reduced viability in most strain backgrounds. Here we show complete...
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