Article
Modifier genes for mouse phosphatidylinositol transfer protein α (vibrator) that bypass juvenile lethality.
Genetics - 1 Apr 2011
Concepcion Dorothy, Johannes Frank, Lo Yuan Hung, Yao Jay, Fong Jerry, Hamilton Bruce A
Abstract excerpt
Phosphatidylinositol transfer proteins (PITPs) mediate lipid signaling and membrane trafficking in eukaryotic cells. Loss-of-function mutations of the gene encoding PITPα in mice result in a range of dosage-sensitive phenotypes, including neurological dysfunction, neurodegeneration, and premature death. We have previously reported genetic suppression of a strong hypomorphic allele, vibrator, by a wild-derived...
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