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ZNF423 patient variants, truncations, and in-frame deletions in mice define an allele-dependent range of midline brain abnormalities

2020-04-05

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<h4>ABSTRACT</h4> Interpreting rare variants remains a challenge in personal genomics, especially for disorders with several causal genes and for genes that cause multiple disorders. ZNF423 encodes a transcriptional regulatory protein that intersects several developmental pathways. ZNF423 has been implicated in rare neurodevelopmental disorders, consistent with midline brain defects in Zfp423 -mutant mice, but...

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Literature Corpus work: 4e442814-6d69-5939-8fb7-b63ca22beaa2
DOI: 10.1101/2020.04.04.024562

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<i>ZNF423</i> patient variants, truncations, and in-frame deletions in mice define an allele-dependent range of midline brain abnormalities

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