Article

Strain-dependent modifier genes determine survival in <i>Zfp423</i> mice

2020-05-13

Abstract excerpt

<h4>ABSTRACT</h4> Zfp423 encodes a transcriptional regulatory protein that interacts with canonical signaling and lineage pathways. Mutations in mouse Zfp423 or its human ortholog ZNF423 are associated with a range of developmental abnormalities reminiscent of ciliopathies, including cerebellar vermis hypoplasia and other midline brain defects. Null mice have reduced viability in most strain backgrounds. Here w...

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Literature Corpus work: 43de5fa4-79a0-5ef9-a70a-0a7e868c1aff
DOI: 10.1101/2020.05.12.091629

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