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Article

Normal myeloid progenitor cell subset-associated gene signatures for acute myeloid leukaemia subtyping with prognostic impact.

PloS one - 1 Jan 2020

Schönherz Anna A, Bødker Julie Støve, Schmitz Alexander, Brøndum Rasmus Froberg, Jakobsen Lasse Hjort, Roug Anne Stidsholt, Severinsen Marianne T, El-Galaly Tarec C, Jensen Paw, Johnsen Hans Erik, Bøgsted Martin, Dybkær Karen

Abstract excerpt

Acute myeloid leukaemia (AML) is characterised by phenotypic heterogeneity, which we hypothesise is a consequence of deregulated differentiation with transcriptional reminiscence of the normal compartment or cell-of-origin. Here, we propose a classification system based on normal myeloid progenitor cell subset-associated gene signatures (MAGS) for individual assignments of AML subtypes. We generated a MAGS...

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Identifiers

PMID: 32324791
DOI: 10.1371/journal.pone.0229593
PMCID: PMC7179860

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