Article

Reactive myelopoiesis and FX-expressing monocyte-derived macrophages triggered by chemotherapy promote cancer lung metastasis

2022-12-10

Abstract excerpt

Chemotherapy offers long-term clinical benefits to many cancer patients. However, several pre-clinical studies have demonstrated that certain cytotoxic drugs enhance metastasis via multiple mechanisms. These studies have mainly focused on tumor cell-derived inflammation. The importance of host responses triggered by chemotherapy in regulating cancer metastasis has not been fully explored. Here, we showed that mult...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3a358ac0-1a3d-507b-900b-8a1af1a9bc93
DOI: 10.1101/2022.12.07.519466

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Reactive myelopoiesis and FX-expressing monocyte-derived macrophages triggered by chemotherapy promote cancer lung metastasisDOI 10.1101/2022.12.07.519466Read

SDF-1/CXCR4 inhibition prevents paradoxical generation of cisplatin-induced pro-metastatic nichesSemantic proximity Read

Patient-Specific Vascularized Tumor Model: Blocking TAM Recruitment with Multispecific Antibodies Targeting CCR2 and CSF-1RSemantic proximity Read

Single-cell transcriptome profiling of the myeloid cells repopulating after chemotherapy identifies a neutrophil-like monocyte subset with pro-tumor activitiesSemantic proximity Read

Macrophages, Neutrophils, and Cancer: A Double Edged SwordSemantic proximity Read

Development of a novel HER2-CAR monocyte cell therapy with controllable proliferation and enhanced anti-tumor efficacySemantic proximity Read

The Endless Saga of Monocyte DiversitySemantic proximity Read

CD61 + LDNs drive cancer metastasis by upregulating CCDC25 expression via DNA-TLR9-NF-kB axis in HCCSemantic proximity Read

Candida albicans-Derived β-Glucan as a Novel Modulator of Tumor Microenvironment: Targeting Macrophage Polarization and Inducing Ferroptosis in Lung CancerSemantic proximity Read

Neutrophils matter: New clinical insights on their role in the progression of metastatic breast cancerSemantic proximity Read

Pro-inflammatory megakaryocyte gene expression in murine models of breast cancerSemantic proximity Read

The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2.Semantic proximity Read

Induction of CXCR2 ligands, stem cell-like phenotype, and metastasis in chemotherapy-resistant breast cancer cells.Semantic proximity Read