Article
The marrow niche controls the cancer stem cell phenotype of disseminated prostate cancer.
Oncotarget - 5 Jul 2016
Shiozawa Yusuke, Berry Janice E, Eber Matthew R, Jung Younghun, Yumoto Kenji, Cackowski Frank C, Yoon Hyeun Joong, Parsana Princy, Mehra Rohit, Wang Jingcheng, McGee Samantha, Lee Eunsohl, Nagrath Sunitha, Pienta Kenneth J, Taichman Russell S
Abstract excerpt
Dissemination of cancer stem cells (CSCs) serves as the basis of metastasis. Recently, we demonstrated that circulating prostate cancer targets the hematopoietic stem cell (HSCs) 'niche' in marrow during dissemination. Once in the niche, disseminated tumor cells (DTCs) may remain dormant for extended periods. As the major function of the HSC niche is to maintain stem cell functions, we hypothesized that the niche...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.