Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ionic Mechanisms of Impulse Propagation Failure in the FHF2-Deficient Heart.

Circulation research - 4 Dec 2020

Park David S, Shekhar Akshay, Santucci John, Redel-Traub Gabriel, Solinas Sergio, Mintz Shana, Lin Xianming, Chang Ernest Whanwook, Narke Deven, Xia Yuhe, Goldfarb Mitchell, Fishman Glenn I

Abstract excerpt

RATIONALE: FHFs (fibroblast growth factor homologous factors) are key regulators of sodium channel (NaV) inactivation. Mutations in these critical proteins have been implicated in human diseases including Brugada syndrome, idiopathic ventricular arrhythmias, and epileptic encephalopathy. The underlying ionic mechanisms by which reduced Nav availability in Fhf2 knockout (Fhf2KO) mice predisposes to abnormal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arrhythmias, Cardiac
Share to Calcium Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Connexin 43

Share to Fibroblast Growth Factors

Share to Gap Junctions

Share to Heart Rate

Share to Mice, 129 Strain

Share to Models, Cardiovascular

Source

Open in PubMed Open full text

Identifiers

PMID: 32962518
DOI: 10.1161/CIRCRESAHA.120.317349
PMCID: PMC7718431

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ionic Mechanisms of Impulse Propagation Failure in the FHF2-Deficient Heart.PMID 32962518Read ↗

Fhf2 gene deletion causes temperature-sensitive cardiac conduction failure.Semantic proximity Read ↗

Conditional knockout of Fgf13 in murine hearts increases arrhythmia susceptibility and reveals novel ion channel modulatory roles.Semantic proximity Read ↗

Fibroblast growth factor homologous factor 13 regulates Na+ channels and conduction velocity in murine hearts.Semantic proximity Read ↗

Loss of K+ currents in heart failure is accentuated in KChIP2 deficient mice.Semantic proximity Read ↗

Role of mutation and pharmacologic block of human KCNH2 in vasculogenesis and fetal mortality: partial rescue by transforming growth factor-β.Semantic proximity Read ↗

Fibroblast growth factor homologous factors in the heart: a potential locus for cardiac arrhythmias.Semantic proximity Read ↗

What happens when cardiac Na channels lose their function? 1--numerical studies of the vulnerable period in tissue expressing mutant channels.Semantic proximity Read ↗

NCX-Mediated Subcellular Ca2+ Dynamics Underlying Early Afterdepolarizations in LQT2 Cardiomyocytes.Semantic proximity Read ↗

Effects of III-IV linker mutations on human heart Na+ channel inactivation gating.Semantic proximity Read ↗

Separable gating mechanisms in a Mammalian pacemaker channel.Semantic proximity Read ↗

Dominant-negative suppression of HCN channels markedly reduces the native pacemaker current I(f) and undermines spontaneous beating of neonatal cardiomyocytes.Semantic proximity Read ↗

Molecular basis of funny current (If) in normal and failing human heartSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.