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Article

Conditional knockout of Fgf13 in murine hearts increases arrhythmia susceptibility and reveals novel ion channel modulatory roles.

Journal of molecular and cellular cardiology - 1 Mar 2017

Wang Xiangchong, Tang He, Wei Eric Q, Wang Zhihua, Yang Jing, Yang Rong, Wang Sheng, Zhang Yongjian, Pitt Geoffrey S, Zhang Hailin, Wang Chuan

Abstract excerpt

The intracellular fibroblast growth factors (iFGF/FHFs) bind directly to cardiac voltage gated Na+ channels, and modulate their function. Mutations that affect iFGF/FHF-Na+ channel interaction are associated with arrhythmia syndromes. Although suspected to modulate other ionic currents, such as Ca2+ channels based on acute knockdown experiments in isolated cardiomyocytes, the in vivo consequences of iFGF/FHF gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28119060
DOI: 10.1016/j.yjmcc.2017.01.009
PMCID: PMC5637556

Genes

FGF13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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