Article
Dominant-negative suppression of HCN channels markedly reduces the native pacemaker current I(f) and undermines spontaneous beating of neonatal cardiomyocytes.
Circulation - 28 Jan 2003
Er Fikret, Larbig Robert, Ludwig Andreas, Biel Martin, Hofmann Franz, Beuckelmann Dirk J, Hoppe Uta C
Abstract excerpt
BACKGROUND: The pacemaker current I(f) contributes to spontaneous diastolic depolarization of cardiac autonomic cells. In heterologous expression, HCN channels exhibit a hyperpolarization-activated inward current similar to I(f). However, the links between HCN genes and native I(f) are largely inferential, and it remains unknown whether I(f) is essential for cardiac pacing. METHODS AND RESULTS: To clarify this...
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