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Article

Role of mutation and pharmacologic block of human KCNH2 in vasculogenesis and fetal mortality: partial rescue by transforming growth factor-β.

Circulation. Arrhythmia and electrophysiology - 1 Apr 2015

Teng Guoqi, Zhao Xiang, Lees-Miller James P, Belke Darrell, Shi Chunhua, Chen Yongxiang, O'Brien Edward R, Fedak Paul W, Bracey Nathan, Cross James C, Duff Henry J

Abstract excerpt

BACKGROUND: N629D KCNH2 is a human missense long-QT2 mutation. Previously, we reported that the N629D/N629D mutation embryos disrupted cardiac looping, right ventricle development, and ablated IKr activity at E9.5. The present study evaluates the role of KCNH2 in vasculogenesis. METHODS AND RESULTS: N629D/N629D yolk sac vessels and aorta consist of sinusoids without normal arborization. Isolated E9.5 +/+ first...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25648353
DOI: 10.1161/CIRCEP.114.001837

Genes

KCNH2
ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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