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Article

DNA methylation of FKBP5 in South African women: associations with obesity and insulin resistance

21 Sept 2020

Abstract excerpt

BACKGROUND: Disruption of the hypothalamic-pituitary-adrenal (HPA) axis, a neuroendocrine system associated with the stress response, has been hypothesized to contribute to obesity development. This may be mediated through epigenetic modulation of HPA axis-regulatory genes in response to metabolic stressors. The aim of this study was to investigate adipose tissue depot-specific DNA methylation differences in the...

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Share to Adipokines, Inflammation, and Metabolic Diseases
Share to Epigenetics and DNA Methylation
Share to Signaling Pathways in Disease

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PMID: 32958048
DOI: 10.1186/s13148-020-00932-3

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