Regulatory functions of FKBP5 intronic regions associated with psychiatric disorders.

doi:10.1016/j.jpsychires.2021.08.014

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Article

Regulatory functions of FKBP5 intronic regions associated with psychiatric disorders.

Journal of psychiatric research - 1 Nov 2021

Mendonça Mariana S, Mangiavacchi Paula M, Rios Álvaro F L

Abstract excerpt

The FKBP5 gene codifies a co-chaperone protein associated with the modulation of glucocorticoid receptor interaction involved in the adaptive stress response. The FKBP5 intracellular concentration affects the binding affinity of the glucocorticoid receptor (GR) to glucocorticoids (GCs). This gene has glucocorticoid response elements (GREs) located in introns 2, 5 and 7, which affect its expression. Recent studies...

Topics

DNA Methylation
Epigenesis, Genetic
Humans
Introns
Mental Disorders
Polymorphism, Single Nucleotide
Tacrolimus Binding Proteins

Source

Open in PubMed

Identifiers

PMID: 34433110
DOI: 10.1016/j.jpsychires.2021.08.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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