FKBP5 polymorphism is associated with insulin resistance in children and adolescents with obesity.

doi:10.1016/j.orcp.2016.11.007

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Article

FKBP5 polymorphism is associated with insulin resistance in children and adolescents with obesity.

Obesity research & clinical practice - 1 Jan 2000

Fichna Marta, Krzyśko-Pieczka Izabela, Żurawek Magdalena, Skowrońska Bogda, Januszkiewicz-Lewandowska Danuta, Fichna Piotr

Abstract excerpt

OBJECTIVE: Since metabolic syndrome shares several clinical features with hypercortisolism, it was hypothesised that genes altering individual glucocorticoid (GC) sensitivity might be implicated in pathogenesis of obesity and its adverse outcomes. FKBP5 gene encodes a chaperon protein in the GC receptor (GR) complex, which modulates steroid action upon target genes. Its functional variant, rs1360780, may enhance...

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Identifiers

PMID: 28007534
DOI: 10.1016/j.orcp.2016.11.007

Genes

FKBP5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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