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The epigenetic signature of systemic insulin resistance in obese women

17 Aug 2016

Abstract excerpt

AIMS/HYPOTHESIS: Insulin resistance (IR) links obesity to type 2 diabetes. The aim of this study was to explore whether white adipose tissue (WAT) epigenetic dysregulation is associated with systemic IR by genome-wide CG dinucleotide (CpG) methylation and gene expression profiling in WAT from insulin-resistant and insulin-sensitive women. A secondary aim was to determine whether the DNA methylation signature in...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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PMID: 27535281
DOI: 10.1007/s00125-016-4074-5

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