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Article

Inhibition of Pyk2 and Src activity improves Cx43 gap junction intercellular communication.

Journal of molecular and cellular cardiology - 1 Dec 2020

Zheng Li, Trease Andrew J, Katsurada Kenichi, Spagnol Gaelle, Li Hanjun, Shi Wen, Duan Bin, Patel Kaushik P, Sorgen Paul L

Abstract excerpt

Identification of proteins that interact with Cx43 has been instrumental in the understanding of gap junction (GJ) regulation. An in vitro phosphorylation screen identified that Protein tyrosine kinase 2 beta (Pyk2) phosphorylated purified Cx43CT and this led us to characterize the impact of this phosphorylation on Cx43 function. Mass spectrometry identified Pyk2 phosphorylates Cx43 residues Y247, Y265, Y267, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32956670
DOI: 10.1016/j.yjmcc.2020.09.004
PMCID: PMC7736531

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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