Article
Ca(2+)-sensitive tyrosine kinase Pyk2/CAK beta-dependent signaling is essential for G-protein-coupled receptor agonist-induced hypertrophy.
Journal of molecular and cellular cardiology - 1 Jun 2004
Hirotani Shinichi, Higuchi Yoshiharu, Nishida Kazuhiko, Nakayama Hiroyuki, Yamaguchi Osamu, Hikoso Shungo, Takeda Toshihiro, Kashiwase Kazunori, Watanabe Tetsuya, Asahi Michio, Taniike Masayuki, Tsujimoto Ikuko, Matsumura Yasushi, Sasaki Terukatsu, Hori Masatsugu, Otsu Kinya
Abstract excerpt
G-protein-coupled receptor agonists including endothelin-1 (ET-1) and phenylephrine (PE) induce hypertrophy in neonatal ventricular cardiomyocytes. Others and we previously reported that Rac1 signaling pathway plays an important role in this agonist-induced cardiomyocyte hypertrophy. In this study reported here, we found that a Ca(2+)-sensitive non-receptor tyrosine kinase, proline-rich tyrosine kinase 2...
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