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Article

Mechanism of v-Src- and mitogen-activated protein kinase-induced reduction of gap junction communication.

American journal of physiology. Cell physiology - 1 Feb 2003

Cottrell G Trevor, Lin Rui, Warn-Cramer Bonnie J, Lau Alan F, Burt Janis M

Abstract excerpt

Connexin (Cx)43 gap junction channels are phosphorylated by numerous protein kinases, with the net effect typically being a reduction in gap junction communication (GJC). This reduction must result from a decrease in channel open probability, unitary conductance, or permselectivity, because previous results suggest that channel number is unaffected. Coexpression of v-Src with wild-type Cx43 (Cx43-wt) but not Cx43...

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Identifiers

PMID: 12388103
DOI: 10.1152/ajpcell.00214.2002
PMCID: PMC2902244

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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