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Sleep, major depressive disorder, and Alzheimer disease: A Mendelian randomization study.

Neurology - 6 Oct 2020

Huang Jian, Zuber Verena, Matthews Paul M, Elliott Paul, Tzoulaki Joanna, Dehghan Abbas

Abstract excerpt

OBJECTIVE: To explore the causal relationships between sleep, major depressive disorder (MDD), and Alzheimer disease (AD). METHODS: We conducted bidirectional 2-sample Mendelian randomization analyses. Genetic associations were obtained from the largest genome-wide association studies currently available in UK Biobank (n = 446,118), Psychiatric Genomics Consortium (n = 18,759), and International Genomics of...

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Identifiers

PMID: 32817390
DOI: 10.1212/WNL.0000000000010463
PMCID: PMC7682841

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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