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Article

Multi-ancestry genome-wide analysis identifies shared genetic effects and common genetic variants for self-reported sleep duration.

Human molecular genetics - 5 Sept 2023

Scammell B H, Tchio C, Song Y, Nishiyama T, Louie T L, Dashti H S, Nakatochi M, Zee P C, Daghlas I, Momozawa Y, Cai J, Ollila H M, Redline S, Wakai K, Sofer T, Suzuki S, Lane J M, Saxena R

Abstract excerpt

Both short (≤6 h per night) and long sleep duration (≥9 h per night) are associated with increased risk of chronic diseases. Despite evidence linking habitual sleep duration and risk of disease, the genetic determinants of sleep duration in the general population are poorly understood, especially outside of European (EUR) populations. Here, we report that a polygenic score of 78 European ancestry sleep duration...

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PMID: 37384397
DOI: 10.1093/hmg/ddad101
PMCID: PMC10656946

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