Article
IP3 receptor-mediated Ca2+ release from acidocalcisomes regulates mitochondrial bioenergetics and prevents autophagy in Trypanosoma cruzi.
Cell calcium - 1 Dec 2020
Chiurillo Miguel A, Lander Noelia, Vercesi Anibal E, Docampo Roberto
Abstract excerpt
In contrast to animal cells, the inositol 1,4,5-trisphosphate receptor of Trypanosoma cruzi (TcIP3R) localizes to acidocalcisomes instead of the endoplasmic reticulum. Here, we present evidence that TcIP3R is a Ca2+ release channel gated by IP3 when expressed in DT40 cells knockout for all vertebrate IP3 receptors, and is required for Ca2+ uptake by T. cruzi mitochondria, regulating pyruvate dehydrogenase...
Topics
- Animals
- Autophagy
- Calcium
- Chickens
- Chlorocebus aethiops
- Energy Metabolism
- Inositol 1,4,5-Trisphosphate
- Inositol 1,4,5-Trisphosphate Receptors
- Life Cycle Stages
- Membrane Potential, Mitochondrial
- Mitochondria
- Mutation
- Phenotype
- Trypanosoma cruzi
- Vero Cells