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Article

A plastid two-pore channel essential for inter-organelle communication and growth of Toxoplasma gondii.

Nature communications - 4 Oct 2021

Li Zhu-Hong, King Thayer P, Ayong Lawrence, Asady Beejan, Cai Xinjiang, Rahman Taufiq, Vella Stephen A, Coppens Isabelle, Patel Sandip, Moreno Silvia N J

Abstract excerpt

Two-pore channels (TPCs) are a ubiquitous family of cation channels that localize to acidic organelles in animals and plants to regulate numerous Ca2+-dependent events. Little is known about TPCs in unicellular organisms despite their ancient origins. Here, we characterize a TPC from Toxoplasma gondii, the causative agent of toxoplasmosis. TgTPC is a member of a novel clad of TPCs in Apicomplexa, distinct from...

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Source

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Identifiers

PMID: 34608145
DOI: 10.1038/s41467-021-25987-5
PMCID: PMC8490419

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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