Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Noninvasive assessment of isocitrate dehydrogenase mutation status in cerebral gliomas by magnetic resonance spectroscopy in a clinical setting.

Journal of neurosurgery - 1 Feb 2018

Tietze Anna, Choi Changho, Mickey Bruce, Maher Elizabeth A, Parm Ulhøi Benedicte, Sangill Ryan, Lassen-Ramshad Yasmin, Lukacova Slavka, Østergaard Leif, von Oettingen Gorm

Abstract excerpt

OBJECTIVE Mutations in the isocitrate dehydrogenase (IDH) genes are of proven diagnostic and prognostic significance for cerebral gliomas. The objective of this study was to evaluate the clinical feasibility of using a recently described method for determining IDH mutation status by using magnetic resonance spectroscopy (MRS) to detect the presence of 2-hydroxyglutarate (2HG), the metabolic product of the mutant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms
Share to Glioma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutarates

Share to Immunohistochemistry

Share to Isocitrate Dehydrogenase

Share to Magnetic Resonance Imaging

Share to Magnetic Resonance Spectroscopy

Share to Sensitivity and Specificity

Source

Identifiers

PMID: 28298040
DOI: 10.3171/2016.10.JNS161793

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Noninvasive assessment of isocitrate dehydrogenase mutation status in cerebral gliomas by magnetic resonance spectroscopy in a clinical setting.PMID 28298040Read ↗

Highly specific determination of IDH status using edited in vivo magnetic resonance spectroscopy.Semantic proximity Read ↗

2-Hydroxyglutarate as an MR spectroscopic predictor of an IDH mutation in gliomas.Semantic proximity Read ↗

2-Hydroxyglutarate MR spectroscopy for prediction of isocitrate dehydrogenase mutant glioma: a systemic review and meta-analysis using individual patient data.Semantic proximity Read ↗

Preoperative Determination of Isocitrate Dehydrogenase Mutation in Gliomas Using Spectral Editing MRS: A Prospective Study.Semantic proximity Read ↗

Magnetic Resonance Spectroscopy for Detection of 2-Hydroxyglutarate as a Biomarker for IDH Mutation in GliomasSemantic proximity Read ↗

Imaging prediction of isocitrate dehydrogenase (IDH) mutation in patients with glioma: a systemic review and meta-analysis.Semantic proximity Read ↗

Noninvasive Identification of Isocitrate Dehydrogenase 1/2 Mutation in Brainstem Gliomas.Semantic proximity Read ↗

Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy.Semantic proximity Read ↗

2-Hydroxyglutarate magnetic resonance spectroscopy in adult brainstem glioma.Semantic proximity Read ↗

In-Vivo Proton Magnetic Resonance Spectroscopy of 2-Hydroxyglutarate in Isocitrate Dehydrogenase-Mutated Gliomas: A Technical Review for Neuroradiologists.Semantic proximity Read ↗

Magnetic resonance imaging and spectroscopic markers for the detection and metabolic characterisation of IDH-mutant gliomasSemantic proximity Read ↗

Noninvasive Quantification of 2-Hydroxyglutarate in Human Gliomas with IDH1 and IDH2 Mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.