Article
GRK4-mediated adiponectin receptor-1 phosphorylative desensitization as a novel mechanism of reduced renal sodium excretion in hypertension.
Clinical science (London, England : 1979) - 30 Sept 2020
Zhang Yan, Wang Shaoxiong, Huang Hefei, Zeng Andi, Han Yu, Zeng Cindy, Zheng Shuo, Ren Hongmei, Wang Yajing, Huang Yu, Jose Pedro A, Ma Xin-Liang, Zeng Chunyu, Chen Ken
Abstract excerpt
Hypertensive patients have impaired sodium excretion. However, the mechanisms are incompletely understood. Despite the established association between obesity/excess adiposity and hypertension, whether and how adiponectin, one of the adipokines, contributes to impaired sodium excretion in hypertension has not been previously investigated. The current study tested the hypothesis that adiponectin promotes...
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