Article

<i>De novo</i> design of transmembrane accessory subunits for fold stabilization and expansion

2026-05-15

Abstract excerpt

Transmembrane (TM) proteins play essential roles in biology as transporters, ion channels, chaperones, enzymes, and mediators of signal transduction. However, membrane proteins often suffer from inefficient folding and intrinsic instability. Misfolding in cells can cause numerous loss-of-function pathologies. Likewise, denaturation upon purification in the laboratory is a critical barrier to structure determinatio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1dedcaf1-d4a9-5054-a2af-898bd03a6e5d
DOI: 10.64898/2026.05.14.725059

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>De novo</i> design of transmembrane accessory subunits for fold stabilization and expansionDOI 10.64898/2026.05.14.725059Read

The ER membrane protein complex acts as a chaperone to promote the biogenesis of multi-bundle membrane proteinsSemantic proximity Read

Subdomain interactions foster the design of two protein pairs with ∼80% sequence identity but different folds.Semantic proximity Read

Mechanism of CFTR correction by type I folding correctorsSemantic proximity Read

Pentameric ligand-gated ion channels exhibit distinct transmembrane domain archetypes for folding/expression and function.Semantic proximity Read

Second-Generation Pharmacological Chaperones: Beyond Inhibitors.Semantic proximity Read

Stepwise introduction of stabilizing mutations reveals nonlinear additive effects in de novo TIM barrels.Semantic proximity Read

Pharmacological chaperones of ATP-sensitive potassium channels: Mechanistic insight from cryoEM structures.Semantic proximity Read

Structure Bioinformatics of Eight Human ATP Synthase Fo Subunits and Their AlphaFold3-Predicted Water-Soluble QTY AnalogsSemantic proximity Read

Small-residue packing motifs modulate the structure and function of a minimal de novo membrane protein.Semantic proximity Read

Automated selection of stabilizing mutations in designed and natural proteins.Semantic proximity Read

Protein-protein interactions in the membrane: sequence, structural, and biological motifs.Semantic proximity Read

Mechanism of CFTR correction by type I folding correctors.Semantic proximity Read