Article
Small design from big alignment: engineering proteins with multiple sequence alignment as the starting point.
Biotechnology letters - 1 Aug 2020
Wang Tianwen, Liang Chen, Hou Yajing, Zheng Mengyuan, Xu Hongju, An Yafei, Xiao Sa, Liu Lu, Lian Shuaibin
Abstract excerpt
Multiple sequence alignment (MSA) is a fundamental way to gain information that cannot be obtained from the analysis of any individual sequence included in the alignment. It provides ways to investigate the relationship between sequence and function from a perspective of evolution. Thus, the MSA of proteins can be employed as a reference for protein engineering. In this paper, we reviewed the recent advances to...
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