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Article

Nicotinamide Metabolism Modulates the Proliferation/Differentiation Balance and Senescence of Human Primary Keratinocytes

15 Feb 2019

Abstract excerpt

Nicotinamide (NAM) is the main precursor of nicotinamide adenine dinucleotide (NAD + ), a coenzyme essential for DNA repair, glycolysis, and oxidative phosphorylation. NAM has anti-aging activity on human skin, but the underlying mechanisms of action are unclear. Using 3-dimensional organotypic skin models, we show that NAM inhibits differentiation of the upper epidermal layers and maintains proliferation in the...

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PMID: 30776433
DOI: 10.1016/j.jid.2019.02.005

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