Article
Genetic variations of aldehyde dehydrogenase 2 and alcohol dehydrogenase 1B are associated with the etiology of atrial fibrillation in Japanese.
Journal of biomedical science - 7 Dec 2016
Nakano Yukiko, Ochi Hidenori, Onohara Yuko, Sairaku Akinori, Tokuyama Takehito, Matsumura Hiroya, Tomomori Shunsuke, Amioka Michitaka, Hironomobe Naoya, Motoda Chikaaki, Oda Nozomu, Chayama Kazuaki, Chen Che-Hong, Gross Eric R, Mochly-Rosen Daria, Kihara Yasuki
Abstract excerpt
BACKGROUND: Alcohol consumption and oxidative stress are well-known risk factors for developing atrial fibrillation (AF). Single nucleotide polymorphisms (SNPs) of alcohol dehydrogenase (ADH1B) and aldehyde dehydrogenase 2 (ALDH2) genes encoding enzymes of alcohol and reactive aldehyde metabolism, respectively, are prevalent among East Asians. Here, we examined whether these SNPs were associated with AF in...
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