Article
Variant Aldehyde Dehydrogenase 2 (ALDH2*2) as a Risk Factor for Mechanical LA Substrate Formation and Atrial Fibrillation with Modest Alcohol Consumption in Ethnic Asians.
Biomolecules - 21 Oct 2021
Hung Chung-Lieh, Sung Kuo-Tzu, Chang Shun-Chuan, Liu Yen-Yu, Kuo Jen-Yuan, Huang Wen-Hung, Su Cheng-Huang, Liu Chuan-Chuan, Tsai Shin-Yi, Liu Chia-Yuan, Lee An-Sheng, Pan Szu-Hua, Wang Shih-Wei, Hou Charles Jia-Yin, Hung Ta-Chuan, Yeh Hung-I
Abstract excerpt
Aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism is a common genetic variant in Asians that is responsible for defective toxic aldehyde and lipid peroxidation metabolism after alcohol consumption. The extent to which low alcohol consumption may cause atrial substrates to trigger atrial fibrillation (AF) development in users with ALDH2 variants remains to be determined. We prospectively enrolled 249 ethnic...
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