Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ALDH2 deficiency induces atrial fibrillation through dysregulated cardiac sodium channel and mitochondrial bioenergetics: A multi-omics analysis.

Biochimica et biophysica acta. Molecular basis of disease - 1 May 2021

Hu Yu-Feng, Wu Chih-Hsun, Lai Tsung-Ching, Chang Yu-Chan, Hwang Ming-Jing, Chang Ting-Yung, Weng Ching-Hui, Chang Peter Mu-Hsin, Chen Che-Hong, Mochly-Rosen Daria, Huang Chi-Ying F, Chen Shih-Ann

Abstract excerpt

Point mutation in alcohol dehydrogenase 2 (ALDH2), ALDH2*2 results in decreased catalytic enzyme activity and has been found to be associated with different human pathologies. Whether ALDH2*2 would induce cardiac remodeling and increase the attack of atrial fibrillation (AF) remains poorly understood. The present study evaluated the effect of ALDH2*2 mutation on AF susceptibility and unravelled the underlying...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aldehyde Dehydrogenase, Mitochondrial
Share to Atrial Fibrillation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Energy Metabolism

Share to Gene Regulatory Networks

Share to Mitochondria

Share to Signal Transduction

Share to Sodium Channels

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 33515676
DOI: 10.1016/j.bbadis.2021.166088
PMCID: PMC8168427

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ALDH2 deficiency induces atrial fibrillation through dysregulated cardiac sodium channel and mitochondrial bioenergetics: A multi-omics analysis.PMID 33515676Read ↗

Aldehyde Dehydrogenase 2 Ameliorates Chronic Alcohol Consumption-Induced Atrial Fibrillation through Detoxification of 4-HNE.Semantic proximity Read ↗

PITX2C Deficiency Promotes Arrhythmogenic Remodeling via Oxidative Stress in Atrial MyocytesSemantic proximity Read ↗

Functional genomics and epigenomics of atrial fibrillation.Semantic proximity Read ↗

ALDH2 Enzyme Deficiency in Diabetic CardiomyopathySemantic proximity Read ↗

Fetal cardiomyocyte phenotype, ketone body metabolism, and mitochondrial dysfunction in the pathology of atrial fibrillation.Semantic proximity Read ↗

ERBB4 deficiency promotes atrial myopathy underlying the atrial fibrillation substrateSemantic proximity Read ↗

Dissecting the Molecular Mechanisms Driving Electropathology in Atrial Fibrillation: Deployment of RNA Sequencing and Transcriptomic AnalysesSemantic proximity Read ↗

Transcriptome Data Analysis of Primary Cardiomyopathies Reveals Perturbations in Arachidonic Acid MetabolismSemantic proximity Read ↗

Identification and validation of oxidative stress-related genes in patients with atrial fibrillationSemantic proximity Read ↗

Bioinformatics and functional experiments reveal that MRC2 inhibits atrial fibrillation via the PPAR signaling pathwaySemantic proximity Read ↗

Advances in Factors Affecting ALDH2 Activity and its Mechanisms.Semantic proximity Read ↗

LNK/SH2B3 loss of function increases susceptibility to murine and human atrial fibrillation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.