The effect of rs1076560 (DRD2) and rs4680 (COMT) on tardive dyskinesia and cognition in schizophrenia subjects.

doi:10.1097/YPG.0000000000000258

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The effect of rs1076560 (DRD2) and rs4680 (COMT) on tardive dyskinesia and cognition in schizophrenia subjects.

Psychiatric genetics - 1 Oct 2020

Punchaichira Toyanji Joseph, Kukshal Prachi, Bhatia Triptish, Deshpande Smita Neelkanth, Thelma B K

Abstract excerpt

OBJECTIVE: The aim of the study is to test the association of a functional variant each in DRD2 and COMT genes with schizophrenia and its endophenotypes. BASIC METHODS: Effect of two functional variants rs1076560 in DRD2 and rs4680 in COMT on (1) schizophrenia (502 cases, 448 controls) diagnosed by Diagnostic and Statistical Manual of Mental Disorders-IV criteria and in subsets with (2) tardive dyskinesia (80...

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Antipsychotic Agents
Catechol O-Methyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Cognition

Gene Frequency

Psychiatric Status Rating Scales

Receptors, Dopamine D2

Schizophrenia

Smoking

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PMID: 32931693
DOI: 10.1097/YPG.0000000000000258
PMCID: PMC10111058

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