Article
ddPCR Analysis Reveals BRAF V600E Mutations Are Infrequent in Isolated Pituitary Langerhans Cell Histiocytosis Patients.
Journal of neuropathology and experimental neurology - 4 Dec 2020
Nellan Anandani, Bodlak Avery, Mirsky David M, Mulcahy Levy Jean, Garrington Timothy P, Foreman Nicholas K, Gilani Ahmed, Hayashi Masanori
Abstract excerpt
Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasia with a highly variable clinical presentation affecting people of all ages. Mutations in BRAF V600E are the most identifiable molecular alteration in LCH although its incidence in pediatric patients with isolated pituitary st...
Topics
- Child
- Child, Preschool
- Female
- Histiocytosis, Langerhans-Cell
- Humans
- Male
- Mutation
- Pituitary Diseases
- Pituitary Gland
- Polymerase Chain Reaction
- Proto-Oncogene Proteins B-raf