Clinicopathological features and BRAFV600E mutations in patients with isolated hypothalamic-pituitary Langerhans cell histiocytosis.

doi:10.1186/s13000-016-0548-5

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Article

Clinicopathological features and BRAFV600E mutations in patients with isolated hypothalamic-pituitary Langerhans cell histiocytosis.

Diagnostic pathology - 19 Oct 2016

Huo Zhen, Lu Tao, Liang Zhiyong, Ping Fan, Shen Jie, Lu Jingjing, Ma Wenbing, Zhao Dachun, Zhong Dingrong

Abstract excerpt

BACKGROUND: Isolated hypothalamic-pituitary Langerhans cell histiocytosis (HPLCH) is very rare. We investigated the clinicopathological characteristics, endocrine function changes, BRAFV600E mutations and treatments of isolated HPLCH. METHODS: We identified seven patients with isolated HPLCH by r...

Topics

Adolescent
Adult
Child
DNA Mutational Analysis
Diabetes Insipidus, Neurogenic
Female
Genetic Predisposition to Disease
Histiocytosis, Langerhans-Cell
Humans
Hypothalamic Diseases
Hypothalamo-Hypophyseal System
Immunohistochemistry
Male
Middle Aged

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Mutation

Phenotype

Pituitary Diseases

Pituitary Gland, Anterior

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Identifiers

PMID: 27760550
DOI: 10.1186/s13000-016-0548-5
PMCID: PMC5070363

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-27760550-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.