Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dissecting Effects of Anti-cancer Drugs and Cancer-Associated Fibroblasts by On-Chip Reconstitution of Immunocompetent Tumor Microenvironments

1 Dec 2018

Abstract excerpt

A major challenge in cancer research is the complexity of the tumor microenvironment, which includes the host immunological setting. Inspired by the emerging technology of organ-on-chip, we achieved 3D co-cultures in microfluidic devices (integrating four cell populations: cancer, immune, endothelial, and fibroblasts) to reconstitute ex vivo a human tumor ecosystem (HER2 + breast cancer). We visualized and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3D Printing in Biomedical Research
Share to HER2/EGFR in Cancer Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30590056
DOI: 10.1016/j.celrep.2018.12.015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dissecting Effects of Anti-cancer Drugs and Cancer-Associated Fibroblasts by On-Chip Reconstitution of Immunocompetent Tumor MicroenvironmentsPMID 30590056Read ↗

<i>Ex vivo</i> quantification of anti-tumor T-cell activity upon anti-PD-1 treatment in patient-derived lung tumor-on-chipSemantic proximity Read ↗

The Tumor-on-Chip: Recent Advances in the Development of Microfluidic Systems to Recapitulate the Physiology of Solid TumorsSemantic proximity Read ↗

Tumor-on-a-chip platform to interrogate the role of macrophages in tumor progression.Semantic proximity Read ↗

Genetic and phenotypic profiling of single living circulating tumor cells from patients with microfluidics.Semantic proximity Read ↗

Tumoroid-on-a-Plate (ToP): Physiologically Relevant Cancer Model Generation and Therapeutic ScreeningSemantic proximity Read ↗

Rapid Microfluidic Formation of Uniform Patient-Derived Breast Tumor SpheroidsSemantic proximity Read ↗

Systematic Growth Factor Profiling Platform for 3D Tumor Models Reveals Estradiol-Responsive Cellular Mechanisms of Immunotherapy ResistanceSemantic proximity Read ↗

Enhancing Patient Lymphocyte Response to Peritoneal Malignancies Using a Personalized Immunocompetent Microfluidic Co-Culture PlatformSemantic proximity Read ↗

Breaking the mold: 3D cell cultures reshaping the future of cancer researchSemantic proximity Read ↗

Tumor-on-chip platforms for transport phenotyping: decoding CAF-driven barriers to drug delivery.Semantic proximity Read ↗

Ovarian cancer-on-chip for patient-specific profiling of treatment responses to sequential chemotherapy and PD-L1 blockadeSemantic proximity Read ↗

Microfluidic technologies for immunotherapy studies on solid tumoursSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.