Article
Supertertiary protein structure affects an allosteric network.
Proceedings of the National Academy of Sciences of the United States of America - 29 Sept 2020
Laursen Louise, Kliche Johanna, Gianni Stefano, Jemth Per
Abstract excerpt
The notion that protein function is allosterically regulated by structural or dynamic changes in proteins has been extensively investigated in several protein domains in isolation. In particular, PDZ domains have represented a paradigm for these studies, despite providing conflicting results. Furthermore, it is still unknown how the association between protein domains in supramodules, consitituting so-called...
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