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Article

AlloSigMA 2: paving the way to designing allosteric effectors and to exploring allosteric effects of mutations.

Nucleic acids research - 2 Jul 2020

Tan Zhen Wah, Guarnera Enrico, Tee Wei-Ven, Berezovsky Igor N

Abstract excerpt

The AlloSigMA 2 server provides an interactive platform for exploring the allosteric signaling caused by ligand binding and/or mutations, for analyzing the allosteric effects of mutations and for detecting potential cancer drivers and pathogenic nsSNPs. It can also be used for searching latent allosteric sites and for computationally designing allosteric effectors for these sites with required agonist/antagonist...

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Identifiers

PMID: 32392302
DOI: 10.1093/nar/gkaa338
PMCID: PMC7319554

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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