Article

Evolutionarily Conserved Allosteric Communication in Protein Tyrosine Phosphatases

2018-10-03

Abstract excerpt

Protein tyrosine phosphatases (PTPs) are an important class of regulatory enzymes that exhibit aberrant activities in a wide range of diseases. A detailed mapping of allosteric communication in these enzymes could, thus, reveal the structural basis of physiologically relevant—and, perhaps, therapeutically informative—perturbations (i.e., mutations, post-translational modifications, or binding events) that influenc...

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Literature Corpus work: 13001086-49f8-52c4-a264-ab595b87edbd
DOI: 10.26434/chemrxiv.7159682.v1

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